[1851 Inbound to Santa Fe] Jerseyville, Illinois 26 March postmark and "10" due rate handstamp on 1851 folded letter addressed to "Dr. Saml. Woodhouse, Santa Fe, Texas, Attached to Capt Sitgreaves exploring party" with the Texas lined out, it would have reached Dr. Woodhouse before he left Santa Fe on 15 August 1851, he reached Ft. Yuma in November
from Wikipedia: The Sitgreaves Expedition Down the Zuni and Colorado Rivers in 1851 was a combined American scientific and military mission to explore the Zuni River, the Little Colorado River and the Colorado River in 1851. Setting out from northern New Mexico, the expedition traveled west across Arizona and then south along the Colorado to Fort Yuma in California.